Gary Hutchison of Westwind German Shorthair Pointers shared on edited version of an article written by Jerold S. Bell, D.V.M. that appeared in the September 1992 American Kennel Club Gazette that details an excellent plan for the line breeding/long term breeding program of a successful kennel. This is based on years of success in their kennel. This article is one of the best I have ever read to use as a guideline for a kennel's breeding program.
One tip they share is:
Successful Breeders use specimens within their line that have at least one truly great trait and breed them with specimens that in turn are great where the other dog is weak. This is the "secret to line breeding" - the only way to successfully fight off the drag of the breed.
To read the entire article you can go to the page, A Guide to A Successful Breeding Program.